Pain Fluctuations in Parkinson's Disease and Their Association with Motor and Non-Motor Fluctuations.

ABSTRACT:

Background

Pain fluctuations are a characteristic phenomenon in advanced Parkinson's disease (PD), but their temporal association with motor and non-motor symptom (NMS) fluctuations remains largely enigmatic. Moreover, data on their importance for disease severity perception and health-related quality-of-life (hr-QoL) is limited.

Objective

To dissect pain fluctuations with respect to pain type and frequency patterns, and their association with motor and non-motor fluctuations.

Methods

Prospective observational cohort study in advanced PD assessing symptom fluctuations by simultaneous hourly ratings using the PD Home diary (Off, On, Dyskinetic state), a pain diary (assessing 9 pain types) and a non-motor diary (10 key NMS) based on validated instruments.

Results

SUBMITTER: Storch A 

PROVIDER: S-EPMC11492001 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature