A convolutional neural network model detecting lasting behavioral changes in mice with kanamycin-induced unilateral inner ear dysfunction.

ABSTRACT: In acute aminoglycoside ototoxicity of the unilateral inner ear, physical abnormalities, such as nystagmus and postural alteration, are relieved within a few days by neural compensation. To examine exploratory behavior over an extended period, behaviors of freely moving mice after unilateral kanamycin injection into the inner ear were recorded in a home cage environment. The tail was excluded from deep learning-mediated object detection because of its delayed movement relative to the body. All detection results were confirmed using a convolutional neural network classification model. In kanamycin-injected mice, the total distance moved in 15 min increased on postoperative day 3. Furthermore, injured mice turned more frequently toward the healthy side up to 17 days after the surgery. This t

SUBMITTER: Noda M 

PROVIDER: S-EPMC11492029 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature