Modulation of Cerebellar Oscillations with Subthalamic Stimulation in Patients with Parkinson's Disease.

ABSTRACT:

Background

Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) has emerged as a potent treatment for alleviating motor symptoms in Parkinson's disease (PD). Despite its effectiveness, the impact of high frequency STN-DBS on cerebellar oscillations remains unclear, posing an intriguing challenge for neural modulation. Given the direct and indirect connections between the STN and cerebellum, we investigated whether STN-DBS affects cerebellar oscillations.

Objective

To observe the effects of STN-DBS on cerebellar oscillations in patients with PD.

Methods

We recruited 15 PD patients receiving STN-DBS. Electroencephalographic (EEG) signals were recorded from cerebellar regions during resting-state conditions in both the OFF-DBS and STN-DBS conditions. Our

SUBMITTER: Bosch TJ 

PROVIDER: S-EPMC11492035 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature