Tissue Factor and Its Cerebrospinal Fluid Protein Profiles in Parkinson's Disease.

ABSTRACT:

Background

Prior investigations have elucidated pathophysiological interactions involving blood coagulation and neurodegenerative diseases. These interactions pertain to age-related effects and a mild platelet antiaggregant function of exogenous α-Synuclein.

Objective

Our study sought to explore whether cerebrospinal fluid (CSF) levels of tissue factor (TF), the initiator of the extrinsic pathway of hemostasis, differ between controls (CON) compared to patients with Parkinson's disease (PD) and dementia with Lewy bodies (DLB), considering that these conditions represent a spectrum of α-Synuclein pathology. We further investigated whether TF levels are associated with longitudinal progression in PD.

Methods

We examined CSF levels of TF in 479 PD patients, 67 patients d

SUBMITTER: Zimmermann M 

PROVIDER: S-EPMC11492048 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature