Small Molecule Decoy of Amyloid-β Aggregation Blocks Activation of Microglia-Like Cells.

ABSTRACT:

Background

Aggregated forms of the amyloid-β (Aβ) peptides which form protofibrils and fibrils in the brain are signatures of Alzheimer's disease (AD). Aggregates are also recognized by microglia, which in early phases may be protective and in later phases contribute to the pathology. We have identified several small molecules, decoys which interfere with Aβ oligomerization and induce other aggregation trajectories leading to aggregated macrostructures which are non-toxic.

Objective

This study investigates whether the small-molecule decoys affect microglial activation in terms of cytokine secretion and phagocytosis of Aβ peptide.

Methods

The effects of the decoys (NSC 69318, NSC 100873, NSC 16224) were analyzed in a model of human THP-1 monocytes differentiated to mic

SUBMITTER: Oasa S 

PROVIDER: S-EPMC11492064 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature