The Relationship Between Physical Activity and Non-Modifiable Risk Factors on Alzheimer's Disease and Brain Health Markers: A UK Biobank Study.

ABSTRACT:

Background

Modifiable (physical activity) and non-modifiable (sex and genotype) risk factors interact to affect Alzheimer's disease (AD) risk. Further investigation is necessary to understand if these factors influence brain volume and cognition.

Objective

The study aimed to assess the effect of physical activity, APOE genotype, and sex on AD risk, brain volume, and cognition.

Methods

UK Biobank data from 2006 to 2023 was accessed. Physical activity was measured by accelerometers, and International Physical Activity Questionnaire. Outcomes were AD incidence; brain volume (ventricular cerebrospinal fluid and total brain); and cognition (executive function, memory, visuospatial ability, processing speed, and reaction time). Logistic and linear regression models were con

SUBMITTER: Spencer FSE 

PROVIDER: S-EPMC11492105 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature