Prospective Study of Lung Function with Prodromal, Clinical Parkinson's Disease, and Mortality.

ABSTRACT:

Background

The association of lung function with the risk of developing prodromal and clinical-diagnosed Parkinson's disease (PD) and with the risk of mortality among individuals with PD remains unknown.

Objective

To prospectively examine the associations of lung function with the risk of prodromal, clinical-diagnosed PD, and PD-related mortality in participants of the UK Biobank.

Methods

Included were 452,518 participants free of PD at baseline. Baseline lung function, including forced expiratory volume in 1-s (FEV1), forced vital capacity (FVC), peak expiratory flow (PEF), and FEV1/FVC ratio, was assessed. Eight prodromal features were measured using self-reported diagnoses, hospital admission, and primary care data. Incident PD cases were identified using linkages

SUBMITTER: Chen X 

PROVIDER: S-EPMC11492123 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature