Prospective associations of interleukin-6 and <i>APOE</i> allele with cognitive decline in biracial community-dwelling older adults: The Chicago Health and Aging Project (CHAP).

ABSTRACT:

Introduction

It is unclear whether inflammation, that is, high interleukin-6 (IL-6) levels, and genetic risk, that is, apolipoprotein E (APOE) ε4 allele, have a compounding effect on cognitive decline (CD).

Methods

We analyzed a subset of participants from the longitudinal cohort study, Chicago Health and Aging Project, comprising 1120 biracial community-dwelling older adults (60% Black and 62% women), and mean follow-up = 6.4 years. We ran adjusted mixed-effects models on2 longitudinal CD.

Results

In APOE ε4 carriers, higher serum IL-6 was not associated with the rate of CD (β = -0.0091 [standard deviation (SD) = 0.0165, p = 0.5800]). Conversely, in non-ε4 carriers, compared to the lower tertile, those with the upper tertile of serum IL-6 levels

SUBMITTER: Ng TKS 

PROVIDER: S-EPMC11492147 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature