Social genomics, cognition, and well-being during the COVID-19 pandemic.

ABSTRACT:

Introduction

Adverse psychosocial exposure is associated with increased pro-inflammatory gene expression and reduced type-1 interferon gene expression known as the conserved transcriptional response to adversity (CTRA). CTRA is not well-studied in cognitive impairment but may contribute to late-life cognitive decline.

Methods

We examined perceived stress, loneliness, well-being, and the impact of coronavirus disease 2019 (COVID-19) and the relationship to the expression of genes associated with the CTRA. Mixed-effect linear models were used to quantify associations between psychosocial variables and CTRA gene expression.

Results

Eudaimonic well-being (EWB) was inversely associated with CTRA gene expression in participants with both normal cognition (NC) and mild cogni

SUBMITTER: Bateman JR 

PROVIDER: S-EPMC11492153 | biostudies-literature | 2024 Oct-Dec

REPOSITORIES: biostudies-literature