Small Airways Obstruction and Mortality: Findings From the UK Biobank.

ABSTRACT:

Background

Small airways obstruction (SAO) is common in general populations. It has been associated with respiratory symptoms, cardiometabolic diseases, and progression to COPD over time. Whether SAO predicts mortality is largely unknown.

Research question

Is spirometry-defined SAO associated with increased mortality?

Methods

Data were analyzed from 252,877 adult participants, aged 40 to 69 years at baseline, in the UK Biobank who had provided good-quality spirometry measurements. SAO was defined as the ratio of the forced expiratory volume in 3 s to the forced expiratory volume in 6 s less than the lower limit of normal. SAO was considered to be isolated if present when the FEV₁/forced expiratory volume in 6 s ratio was normal (ie, greater than the lower l

SUBMITTER: Quintero Santofimio V 

PROVIDER: S-EPMC11492227 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature