Entactogen Effects of Ketamine: A Reverse-Translational Study.

ABSTRACT:

Objective

The authors sought to assess the prosocial, entactogen effects of ketamine.

Methods

Pleasure from social situations was assessed in a sample of participants with treatment-resistant depression from randomized, double-blind, placebo-controlled studies, using four items of the Snaith-Hamilton Pleasure Scale (SHAPS) at five time points over 1 week following treatment with ketamine (0.5 mg/kg intravenously) or placebo. The primary endpoint was postinfusion self-reported pleasure on the four SHAPS items pertaining to social situations, including the item on helping others, between the ketamine and placebo groups. In a rodent experiment, the impact of ketamine on helping behavior in rats was assessed using the harm aversion task. The primary endpoint was a reduction in l

SUBMITTER: Hess EM 

PROVIDER: S-EPMC11492270 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature