Landmark-based auto-contouring of clinical target volumes for radiotherapy of nasopharyngeal cancer.

ABSTRACT:

Background

The delineation of clinical target volumes (CTVs) for radiotherapy for nasopharyngeal cancer is complex and varies based on the location and extent of disease.

Purpose

The current study aimed to develop an auto-contouring solution following one protocol guidelines (NRG-HN001) that can be adjusted to meet other guidelines, such as RTOG-0225 and the 2018 International guidelines.

Methods

The study used 2-channel 3-dimensional U-Net and nnU-Net framework to auto-contour 27 normal structures in the head and neck (H&N) region that are used to define CTVs in the protocol. To define the CTV-Expansion (CTV1 and CTV2) and CTV-Overall (the outer envelope of all the CTV contours), we used adjustable morphological geometric landmarks and mimicked physician interpretati

SUBMITTER: Sjogreen C 

PROVIDER: S-EPMC11492310 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature