Benefits of exercise on cognitive impairment in alcohol use disorder following alcohol withdrawal.

ABSTRACT: Although most cognitive impairments induced by prolonged alcohol consumption tend to improve within the initial months of abstinence, there is evidence suggesting certain cognitive deficits may persist. This study aimed to investigate the impact of aerobic exercise on learning and memory in alcohol use disorder (AUD) mice following a period of abstinence from alcohol. We also sought to assess the levels of monoamine neurotransmitters in the hippocampus. To this end, we established an AUD mouse model through a two-bottle choice (sucrose fading mode and normal mode) and chronic intermittent alcohol vapor (combined with intraperitoneal injection) and randomly allocated mice into exercise groups to undergo treadmill training. Learning and memory abilities were assessed through the Morris water

SUBMITTER: Lyu Z 

PROVIDER: S-EPMC11492329 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature