Drug retention after intradiscal administration.

ABSTRACT: Intradiscal drug delivery is a promising strategy for treating intervertebral disk degeneration (IVDD). Local degenerative processes and intrinsically low fluid exchange are likely to influence drug retention. Understanding their connection will enable the optimization of IVDD therapeutics. Release and retention of an inactive hydrophilic fluorine-19 labeled peptide (¹⁹F-P) as model for regenerative peptides was studied in a whole IVD culture model by measuring the ¹⁹F-NMR (nuclear magnetic resonance) signal in culture media and IVD tissue extracts. In another set-up, noninvasive near-infrared imaging was used to visualize IR-780, as hydrophobic small molecular drug model, retention upon injection into healthy and degenerative caudal IVDs in a rat model of disk degene

SUBMITTER: Rudnik-Jansen I 

PROVIDER: S-EPMC11492387 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature