Preclinical evaluation of a novel endovascular thrombectomy device in a modified swine model for iliac vein thrombosis.

ABSTRACT:

Objective

To evaluate the safety and efficacy of a novel endovascular thrombectomy device in a modified swine model of iliac vein thrombosis.

Methods

A modified swine model for iliac vein thrombosis was created using proximal‒distal balloon occlusion combined with autologous venous thrombus and thrombin injections. The safety and efficacy of the newly developed Zylox endovascular thrombectomy system were evaluated in this animal model and its performance was compared with that of the AcoStream aspiration thrombectomy device.

Results

Bilateral iliac vein thrombosis models were successfully created in 12 swine, with 23 iliac veins used for device testing and one for anatomical observation. The thrombus length in the Zylox group was greater than in the AcoStream group (9

SUBMITTER: Zeng Q 

PROVIDER: S-EPMC11492447 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature