Subgenomic flaviviral RNAs and human proteins: in silico exploration of anti-host defense mechanisms.

ABSTRACT: Flaviviruses pose significant global health threats, infecting over 300 million people annually. Among their evasion strategies, the production of subgenomic flaviviral RNAs (sfRNAs) from the 3' UTR of viral genomes is particularly notable. Utilizing a comprehensive in silico approach with the catRAPID algorithm, we analyzed over 300,000 interactions between sfRNAs and human proteins derived from more than 8000 flavivirus genomes, including Dengue, Zika, Yellow Fever, West Nile, and Japanese Encephalitis viruses. By providing the first extensive atlas of sfRNA interactions, we offer new insights into how flaviviruses can manipulate host cellular machinery to facilitate viral survival and persistence. Our study not only validated known interactions but also revealed novel huma

SUBMITTER: Delli Ponti R 

PROVIDER: S-EPMC11492465 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature