Host-microbe interaction-mediated resistance to DSS-induced inflammatory enteritis in sheep.

ABSTRACT:

Background

The disease resistance phenotype is closely related to immunomodulatory function and immune tolerance and has far-reaching implications in animal husbandry and human health. Microbes play an important role in the initiation, prevention, and treatment of diseases, but the mechanisms of host-microbiota interactions in disease-resistant phenotypes are poorly understood. In this study, we hope to uncover and explain the role of microbes in intestinal diseases and their mechanisms of action to identify new potential treatments.

Methods

First, we established the colitis model of DSS in two breeds of sheep and then collected the samples for multi-omics testing including metagenes, metabolome, and transcriptome. Next, we made the fecal bacteria liquid from the four groups

SUBMITTER: Yan S 

PROVIDER: S-EPMC11492479 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature