Tumor volume features predict survival outcomes for patients diagnosed with diffuse intrinsic pontine glioma.

ABSTRACT:

Background

Diffuse intrinsic pontine glioma (DIPG) is a fatal childhood central nervous system tumor. Diagnosis and monitoring of tumor response to therapy is based on magnetic resonance imaging (MRI). MRI-based analyses of tumor volume and appearance may aid in the prediction of patient overall survival (OS).

Methods

Contrast-enhanced T1- and FLAIR/T2-weighted MR images were retrospectively collected from children with classical DIPG diagnosed by imaging (n = 43 patients). MRI features were evaluated at diagnosis (n = 43 patients) and post-radiation (n = 40 patients) to determine OS outcome predictors. Features included 3D tumor volume (T_wv), contrast-enhancing tumor core volume (T_c), T_c relative to T_wv (T

SUBMITTER: Spencer D 

PROVIDER: S-EPMC11492488 | biostudies-literature | 2024 Jan-Dec

REPOSITORIES: biostudies-literature