Gasdermin D promotes development of intestinal tumors through regulating IL-1β release and gut microbiota composition.

ABSTRACT: The interplay between gut microbiota and host is crucial for maintaining host health. When this balance is broken, various diseases can arise, including colorectal cancer (CRC). However, the mechanism by which gut microbiota and host interactions mediate CRC development remains unclear. Here, we found that Gasdermin D (GSDMD), an inflammasome effector responsible for forming membrane pores to mediate cell pyroptosis, was upregulated in both human and mouse intestinal tumor samples. GSDMD deficiency significantly suppressed intestinal tumor development in Apc^min/+ mice, a spontaneous CRC mouse model. Apc^min/+Gsdmd^-/- mice exhibited reduced IL-1β release in the intestine, and the administration of recombinant mouse IL-1β partially restored intestinal tumor de

SUBMITTER: Gao H 

PROVIDER: S-EPMC11492562 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature