Impact of Structural Differences on the Modeled Cost-Effectiveness of Noninvasive Prenatal Testing.

ABSTRACT:

Background

Noninvasive prenatal testing (NIPT) was developed to improve the accuracy of prenatal screening to detect chromosomal abnormalities. Published economic analyses have yielded different incremental cost-effective ratios (ICERs), leading to conclusions of NIPT being dominant, cost-effective, and cost-ineffective. These analyses have used different model structures, and the extent to which these structural variations have contributed to differences in ICERs is unclear.

Aim

To assess the impact of different model structures on the cost-effectiveness of NIPT for the detection of trisomy 21 (T21; Down syndrome).

Methods

A systematic review identified economic models comparing NIPT to conventional screening. The key variations in identified model structures were th

SUBMITTER: Salisbury A 

PROVIDER: S-EPMC11492563 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature