ViCE: An automated and quantitative program to assess intestinal tissue morphology.

ABSTRACT:

Background and objective

The tissue morphology of the intestinal surface is architecturally complex with finger-like projections called villi, and glandular structures called crypts. The ratio of villus height-to-crypt depth ratio (Vh:Cd) is used to quantitatively assess disease severity and response to therapy for intestinal enteropathies, such as celiac disease and is currently quantified manually. Given the time required, manual Vh:Cd measurements have largely been limited to clinical trials and are not used widely in clinical practice. We developed ViCE (Villus Crypt Evaluator), a user-friendly software that automatically quantifies histological parameters in standard hematoxylin and eosin-stained intestinal biopsies.

Methods

ViCE is based on mathematical morphology oper

SUBMITTER: La J 

PROVIDER: S-EPMC11492601 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature