Integrating metabolomics and proteomics to identify novel drug targets for heart failure and atrial fibrillation.

ABSTRACT:

Background

Altered metabolism plays a role in the pathophysiology of cardiac diseases, such as atrial fibrillation (AF) and heart failure (HF). We aimed to identify novel plasma metabolites and proteins associating with cardiac disease.

Methods

Mendelian randomisation (MR) was used to assess the association of 174 metabolites measured in up to 86,507 participants with AF, HF, dilated cardiomyopathy (DCM), and non-ischemic cardiomyopathy (NICM). Subsequently, we sourced data on 1567 plasma proteins and performed cis MR to identify proteins affecting the identified metabolites as well as the cardiac diseases. Proteins were prioritised on cardiac expression and druggability, and mapped to biological pathways.

Results

We identified 35 metabolites associating with cardiac

SUBMITTER: van Vugt M 

PROVIDER: S-EPMC11492627 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature