Linear epitopes of PRRSV-1 envelope proteins ectodomains are not correlated with broad neutralization.

ABSTRACT:

Background

Neutralizing antibodies against PRRSV are capable of conferring protection against viral reinfection, but they tend to be strain specific and usually have poor cross-reactivity. Nonetheless, it has been described that there are individuals capable of efficiently neutralizing viruses of different origin, so it is expected that there are conserved neutralizing epitopes relevant for broad neutralization. However, although immunodominant regions and neutralizing epitopes have been described in different envelope proteins, their role in broad neutralization is unknown. The main objective of this study was to determine whether the linear epitopes existing in the ectodomains of PRRSV envelope proteins play a role in cross-neutralization.

Results

A pepscan analysis was ca

SUBMITTER: Castillo-Perez J 

PROVIDER: S-EPMC11492654 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature