Identification of three subtypes of ovarian cancer and construction of prognostic models based on immune-related genes.

ABSTRACT:

Background

Immunotherapy has revolutionized the treatment of ovarian cancer (OC), but different immune microenvironments often constrain the efficacy of immunotherapeutic interventions. Therefore, there is an imperative to delineate novel immune subtypes for development of efficacious immunotherapeutic strategies.

Methods

The immune subtypes of OC were identified by consensus cluster analysis. The differences in clinical features, genetic mutations, mRNA stemness (mRNAsi) and immune microenvironments were analyzed among subtypes. Subsequently, prognostic risk models were constructed based on differentially expressed genes (DEGs) of the immune subtypes using weighted correlation network analysis.

Results

OC patients were classified into three immune subtypes with disti

SUBMITTER: Gao W 

PROVIDER: S-EPMC11492668 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature