Molecular mechanisms underlying the neural correlates of working memory.

ABSTRACT:

Background

Working memory (WM), a core component of executive functions, relies on a dedicated brain system that maintains and stores information in the short term. While extensive neuroimaging research has identified a distributed set of neural substrates relevant to WM, their underlying molecular mechanisms remain enigmatic. This study investigated the neural correlates of WM as well as their underlying molecular mechanisms.

Results

Our voxel-wise analyses of resting-state functional MRI data from 502 healthy young adults showed that better WM performance (higher accuracy and shorter reaction time of the 3-back task) was associated with lower functional connectivity density (FCD) in the left inferior temporal gyrus and higher FCD in the left anterior cingulate cortex. A co

SUBMITTER: Xu X 

PROVIDER: S-EPMC11492763 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature