Effect of weight-maintaining ketogenic diet on glycemic control and insulin sensitivity in obese T2D subjects.

ABSTRACT:

Introduction

Low carbohydrate ketogenic diets have received renewed interest for the treatment of obesity and type 2 diabetes. These diets promote weight loss, improve glycemic control, and reduce insulin resistance. However, whether the improvements in glycemic control and insulin sensitivity are secondary to the weight loss or result from a direct effect of hyperketonemia is controversial.

Research design and methods

29 overweight obese subjects were randomized to one of three dietary interventions for 10 days: (1) Weight-maintaining standard diet; (2) Weight-maintaining ketogenic diet; (3) Weight-maintaining ketogenic diet plus supplementation with the ketone ester of beta-hydroxybutyrate (β-OH-B), 8 g every 8 hours. At baseline, all subjects had oral glucose tolerance te

SUBMITTER: Merovci A 

PROVIDER: S-EPMC11492932 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature