Comorbidity burden on mortality in patients with systemic sclerosis.

ABSTRACT:

Introduction

Systemic sclerosis (SSc) is a serious life-threatening tissue disease. A significant aspect of its mortality arises from comorbid conditions. Our study aimed at mapping out the prevalence of these comorbidities and their relation to mortality, thus creating a 'comorbidome'.

Methods

In our retrospective, single-centre observational study, we recorded each patient's data, including demographic informations, vital stats and SSc-related organ involvement, along with the presence or absence of 14 predefined comorbidities. We also documented the dates of their initial and most recent visits. To construct survival curves, we used the Kaplan-Meier method, followed by a Cox regression model for multivariate analysis.

Results

Our study involved 400 participants, 74

SUBMITTER: Fauthoux T 

PROVIDER: S-EPMC11492939 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature