YTHDF3 gene polymorphisms increase Wilms tumor risk in Chinese girls.

ABSTRACT: Wilms tumor is a prevalent pediatric tumor influenced by various genetic factors. m⁶A modification is a common nucleotide modification that plays a role in a variety of cancers. As a "reader", YTHDF3 is essential for recognizing m⁶A modifications. However, the association between YTHDF3 gene polymorphisms and Wilms tumor susceptibility has not been previously reported. A five-center case‒control study including 414 patients and 1199 controls was conducted to explore the relationship between YTHDF3 gene polymorphisms and Wilms tumor susceptibility. The samples were genotyped via TaqMan real-time quantitative polymerase chain reaction. Odds ratios (ORs) and 95% confidence intervals (CIs) were utilized as indicators to assess their correlation. The YTHDF

SUBMITTER: Deng C 

PROVIDER: S-EPMC11493011 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature