ALKBH5 modulation of ferroptosis in recurrent miscarriage: implications in cytotrophoblast dysfunction.

ABSTRACT:

Background

As one of the most common and abundant internal modifications of eukaryotic mRNA, N⁶-methyladenosine (m⁶A) modifications are closely related to placental development. Ferroptosis is a newly discovered form of programmed cell death. During placental development, placental trophoblasts are susceptible to ferroptosis. However, the interactions of m⁶A and ferroptosis in trophoblast physiology and injury are unclear.

Methods

Recurrent miscarriage (RM) was selected as the main gestational disease in this study. Published data (GSE76862) were used to analyze the gene expression profiles in patients with RM. The extent of m⁶A modification in total RNA of villous tissues between patients with RM and healthy controls (HC) was comp

SUBMITTER: Qin C 

PROVIDER: S-EPMC11493020 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature