The underlying mechanisms of FGF2 in carotid atherosclerotic plaque development revealed by bioinformatics analysis.

ABSTRACT:

Introduction

The purpose of this study was to explore the regulatory mechanisms of FGF2 in carotid atherosclerotic plaque development using bioinformatics analysis.

Material and methods

Expression profiles of 32 atheroma plaque (AP) and 32 paired distant macroscopically intact (DMI) tissues samples in the GSE43292 dataset were downloaded from the Gene Expression Omnibus database. Following identification of differential expression genes (DEGs), correlation analysis of fibroblast growth factor 2 (FGF2) and DEGs was conducted. Subsequently, functional enrichment analysis and the protein-protein interaction network for FGF2 significantly correlated DEGs were constructed. Then, microRNAs (miRNAs) that regulated FGF2 and regulatory pairs of long noncoding RNA (lncRNA)-miRNA were

SUBMITTER: Li J 

PROVIDER: S-EPMC11493040 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature