Optimal protein allocation controls the inhibition of GltA and AcnB in Neisseria gonorrhoeae.

ABSTRACT: Neisseria gonorrhea (Ngo) is a major concern for global public health due to its severe implications for reproductive health. Understanding its metabolic phenotype is crucial for comprehending its pathogenicity. Despite Ngo's ability to encode tricarboxylic acid (TCA) cycle proteins, GltA and AcnB, their activities are notably restricted. To investigate this phenomenon, we used the iNgo_557 metabolic model and incorporated a constraint on total cellular protein content. Our results indicate that low cellular protein content severely limits GltA and AcnB activity, leading to a shift toward acetate overflow for Adenosine triphosphate (ATP) production, which is more efficient in terms of protein usage. Surprisingly, increasing cellular protein content alleviates this restriction on GltA and A

SUBMITTER: Shahreen N 

PROVIDER: S-EPMC11493098 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature