Phenotypic diversity of type III secretion system activity in enteropathogenic <i>Escherichia coli</i> clinical isolates.

ABSTRACT: Introduction. Enteropathogenic Escherichia coli (EPEC) strains pose a significant threat as a leading cause of severe childhood diarrhoea in developing nations. EPEC pathogenicity relies on the type III secretion system (T3SS) encoded by the locus of enterocyte effacement (LEE), facilitating the secretion and translocation of bacterial effector proteins.Gap Statement. While the regulatory roles of PerC (plasmid-encoded regulator) and GrlA (global regulator of LEE-activator) in ler expression and LEE gene activation are well-documented in the EPEC prototype strain E2348/69, understanding the variability in LEE gene expression control mechanisms among clinical EPEC isolates remains an area requiring further investigation.Aim. This study aims to explore the

SUBMITTER: Contreras CA 

PROVIDER: S-EPMC11493143 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature