Diversity, functional classification and genotyping of SHV β-lactamases in Klebsiella pneumoniae.

ABSTRACT: Interpreting the phenotypes of bla _SHV alleles in Klebsiella pneumoniae genomes is complex. Whilst all strains are expected to carry a chromosomal copy conferring resistance to ampicillin, they may also carry mutations in chromosomal bla _SHV alleles or additional plasmid-borne bla _SHV alleles that have extended-spectrum β-lactamase (ESBL) activity and/or β-lactamase inhibitor (BLI) resistance activity. In addition, the role of individual mutations/a changes is not completely documented or understood. This has led to confusion in the literature and in antimicrobial resistance (AMR) gene databases [e.g. the National Center for Biotechnology Information (NCBI) Reference Gene Catalog and the β-lactamase database (BLDB)] over the spec

SUBMITTER: Tsang KK 

PROVIDER: S-EPMC11493186 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature