Meta-analysis of genome-wide association studies of stable warfarin dose in patients of African ancestry.

ABSTRACT:

Abstract

Warfarin dose requirements are highly variable because of clinical and genetic factors. Although genetic variants influencing warfarin dose have been identified in European and East Asian populations, more work is needed to identify African-specific genetic variants to help optimize warfarin dosing. We performed genome-wide association studies (GWASs) in 4 African cohorts from Uganda, South Africa, and Zimbabwe, totaling 989 warfarin-treated participants who reached stable dose and had international normalized ratios within therapeutic ranges. We also included 2 African American cohorts recruited by the International Warfarin Pharmacogenetics Consortium (n = 316) and the University of Alabama at Birmingham (n = 199). After the GWAS, we performed standard error-weighted met

SUBMITTER: Asiimwe IG 

PROVIDER: S-EPMC11493193 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature