Corneal nerve loss in adolescents with obesity and acanthosis nigricans.

ABSTRACT:

Background/aim

Obesity and related metabolic abnormalities in adults are associated with peripheral neuropathy. Acanthosis nigricans (AN) is associated with insulin resistance, fatty liver, hyperlipidemia and glucose intolerance, all of which are risk factors for neuropathy. The aim of this study was to investigate if obese adolescents with AN have evidence of small nerve fiber damage.

Material and methods

Adolescents with obesity with and without AN underwent body composition analysis, assessment of vibration perception threshold (VPT), monofilament sensitivity and corneal confocal microscopy (CCM) to quantify corneal nerve fiber density (CNFD), branch density (CNBD), length (CNFL) and inferior whorl length (IWL).

Results

Forty-six participants with obesity with (n =

SUBMITTER: Gad H 

PROVIDER: S-EPMC11493272 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature