Unifying approaches from statistical genetics and phylogenetics for mapping phenotypes in structured populations.

ABSTRACT: In both statistical genetics and phylogenetics, a major goal is to identify correlations between genetic loci or other aspects of the phenotype or environment and a focal trait. In these 2 fields, there are sophisticated but disparate statistical traditions aimed at these tasks. The disconnect between their respective approaches is becoming untenable as questions in medicine, conservation biology, and evolutionary biology increasingly rely on integrating data from within and among species, and once-clear conceptual divisions are becoming increasingly blurred. To help bridge this divide, we lay out a general model describing the covariance between the genetic contributions to the quantitative phenotypes of different individuals. Taking this approach shows that standard models in both statis

SUBMITTER: Schraiber JG 

PROVIDER: S-EPMC11493298 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature