Human visceral leishmaniasis and polymorphisms in interleukin-coding genes: a systematic review.

ABSTRACT: Visceral leishmaniasis (VL) is a neglected disease that is typical of tropical and subtropical parts of the world and is caused by the trypanosomatid Leishmania donovani complex. This disease is a multifactorial condition that involves parasitic, environmental, and immunogenetic characteristics. Genetic changes in genes encoding cytokines may be associated with changes in their expression and, consequently, with the development of clinical resistance or susceptibility to the disease. This systematic review and meta-analysis aimed to assess whether single nucleotide polymorphisms (SNPs) in interleukin genes influence the clinical consequences of visceral leishmaniasis infection. To this end, we carried out a systematic review and meta-analysis with structured searches in the EMBASE,

SUBMITTER: Vieira AVB 

PROVIDER: S-EPMC11493340 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature