Vibration-controlled transient elastography for significant fibrosis in treatment-naive chronic hepatitis B patients: A systematic review and meta-analysis.

ABSTRACT:

Backgrounds/aims

Accurate diagnosis of significant liver fibrosis in patients with chronic hepatitis B (CHB) is crucial when determining whether to initiate antiviral treatment (AVT). We conduct a meta-analysis to assess the diagnostic performance of vibration-controlled transient elastography (VCTE) for significant liver fibrosis in AVT-naïve CHB patients with serum alanine transaminase (ALT) levels within 5-fold the upper limit of normal (ULN).

Methods

The Ovid-Medline, EMBASE, Cochrane, and KoreaMed databases were searched to identify studies that compared the performance of VCTE and liver biopsy (reference standard) when diagnosing significant liver fibrosis (≥F2) in AVT-naïve CHB patients with ALT within 5-fold the ULN. A hierarchical summary receiver operating characte

SUBMITTER: Kim MN 

PROVIDER: S-EPMC11493358 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature