Working memory gating in obesity is moderated by striatal dopaminergic gene variants.

ABSTRACT: Everyday life requires an adaptive balance between distraction-resistant maintenance of information and the flexibility to update this information when needed. These opposing mechanisms are proposed to be balanced through a working memory gating mechanism. Prior research indicates that obesity may elevate the risk of working memory deficits, yet the underlying mechanisms remain elusive. Dopaminergic alterations have emerged as a potential mediator. However, current models suggest these alterations should only shift the balance in working memory tasks, not produce overall deficits. The empirical support for this notion is currently lacking, however. To address this gap, we pooled data from three studies (N = 320) where participants performed a working memory gating task. Higher BMI was asso

SUBMITTER: Herzog N 

PROVIDER: S-EPMC11493406 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature