DGRPool, a web tool leveraging harmonized <i>Drosophila</i> Genetic Reference Panel phenotyping data for the study of complex traits.

ABSTRACT: Genome-wide association studies have advanced our understanding of complex traits, but studying how a GWAS variant can affect a specific trait in the human population remains challenging due to environmental variability. Drosophila melanogaster is in this regard an excellent model organism for studying the relationship between genetic and phenotypic variation due to its simple handling, standardized growth conditions, low cost, and short lifespan. The Drosophila Genetic Reference Panel (DGRP) in particular has been a valuable tool for studying complex traits, but proper harmonization and indexing of DGRP phenotyping data is necessary to fully capitalize on this resource. To address this, we created a web tool called DGRPool (dgrpool.epfl.ch), which aggregates phenotypi

SUBMITTER: Gardeux V 

PROVIDER: S-EPMC11493408 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature