Emergent ecological patterns and modelling of gut microbiomes in health and in disease.

ABSTRACT: Recent advancements in next-generation sequencing have revolutionized our understanding of the human microbiome. Despite this progress, challenges persist in comprehending the microbiome's influence on disease, hindered by technical complexities in species classification, abundance estimation, and data compositionality. At the same time, the existence of macroecological laws describing the variation and diversity in microbial communities irrespective of their environment has been recently proposed using 16s data and explained by a simple phenomenological model of population dynamics. We here investigate the relationship between dysbiosis, i.e. in unhealthy individuals there are deviations from the "regular" composition of the gut microbial community, and the existence of macro-ecological e

SUBMITTER: Pasqualini J 

PROVIDER: S-EPMC11493414 | biostudies-literature | 2024 Sep

REPOSITORIES: biostudies-literature