Experimental acute <i>Clostridium perfringens</i> type D enterotoxemia in sheep is not characterized by specific renal lesions.

ABSTRACT: Type D enterotoxemia, caused by Clostridium perfringens epsilon toxin (ETX), is one of the most economically important clostridial diseases of sheep. Acute type D enterotoxemia is characterized by well-documented lesions in the nervous, cardiocirculatory, and pulmonary systems. However, discrepancies and confusion exist as to whether renal lesions are part of the spectrum of lesions of this condition, which is controversial considering that for many decades it has been colloquially referred to as "pulpy kidney disease." Here, the authors assess renal changes in an experimental model of acute type D enterotoxemia in sheep and evaluate the possible role of ETX in their genesis. Four groups of 6 sheep each were intraduodenally inoculated with either a wild-type virulent C. perfringe

SUBMITTER: Giannitti F 

PROVIDER: S-EPMC11493415 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature