Effect of smoking status on immunotherapy for lung cancer: a systematic review and meta-analysis.

ABSTRACT:

Background

Recent studies have yielded conflicting results regarding the relationship between smoking history and the effectiveness of immune checkpoint inhibitors (ICIs) for advanced lung cancer. While some studies have suggested that smoking may enhance the response to immunotherapy in patients with lung cancer, other findings indicate the contrary. Therefore, we conducted a systematic review and meta-analysis to thoroughly examine this association.

Methods

We searched the PubMed, Embase, and Scopus databases for clinical trials comparing immunotherapy with conventional chemotherapy as the primary treatment for advanced lung cancer. A random effects model was used to synthesize hazard ratios (HRs) and 95% confidence intervals (CIs) for overall survival (OS). We also conduc

SUBMITTER: Luo D 

PROVIDER: S-EPMC11493588 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature