Association between statin use and immune-related adverse events in patients treated with immune checkpoint inhibitors: analysis of the FAERS database.

ABSTRACT:

Background

Understanding the risk relationship between statin use and immune-related adverse events (irAEs) in patients undergoing immune checkpoint inhibitors (ICIs) therapy is crucial for optimizing oncological management.

Objective

This study aimed to investigate whether the use of statins increases the risk of irAEs in patients receiving ICI therapy.

Methods

This study primarily utilized data from FAERS database. Multivariable logistic regression was the principal method of analysis, and the Benjamini-Hochberg procedure was employed to adjust for multiple hypothesis testing.

Results

In a group of 145,214 patients undergoing ICI therapy, 9,339 reported using statin medications. Multivariable analysis indicated an increased risk of irAEs among statin users (O

SUBMITTER: Yang H 

PROVIDER: S-EPMC11493589 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature