Exploring the heterogeneity of hepatic and pancreatic fat deposition in obesity: implications for metabolic health.

ABSTRACT:

Objective

This retrospective observational study investigates the heterogeneity of hepatic and pancreatic fat deposition and its implications for metabolic health in individuals with obesity.

Methods

A total of 706 patients with obesity underwent an MRI to quantify liver and pancreatic fat. Patients were classified into four groups based on fat deposition: no fat (None), fatty pancreas only (NAFPD), fatty liver only (NAFLD), and both conditions (NAFLD+NAFPD). Biochemical profiles, insulin resistance (Homeostatic Model Assessment for Insulin Resistance, HOMA-IR), and β-cell function were analyzed. A series of multiple linear regressions were used to investigate the independent effects of characteristics on glucose, insulin, and C-peptide at 0h. Another multiple linear regress

SUBMITTER: Deng M 

PROVIDER: S-EPMC11493592 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature