The mutated in colorectal cancer (<i>MCC</i>) gene can serve as a potential biomarker of glioblastoma.

ABSTRACT:

Introduction

The mutated in colorectal cancer (MCC) gene was initially identified as a candidate tumor suppressor gene in colorectal cancer, acting as a negative regulator of cell cycle progression. However, its functional roles in brain tumors, particularly glioblastoma, remain largely unexplored. This study reveals a significant association between MCC status and glioblastoma.

Methods

We explored MCC expression in the glioblastoma database, patient samples, and cell lines. We investigated the proliferation and migration of the cell lines in MCC gene knockdown using small interfering RNA.

Results

In vitro analyses revealed elevated protein and mRNA levels of MCC in several glioblastoma cell lines (U118MG and T98G). Silencing MCC expression via siRNA-mediated k

SUBMITTER: Nguyen H 

PROVIDER: S-EPMC11493605 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature