Toward understanding the brain tissue behavior due to preconditioning: an experimental study and RVE approach.

ABSTRACT: Brain tissue under preconditioning, as a complex issue, refers to repeated loading-unloading cycles applied in mechanical testing protocols. In previous studies, only the mechanical behavior of the tissue under preconditioning was investigated; However, the link between macrostructural mechanical behavior and microstructural changes in brain tissue remains underexplored. This study aims to bridge this gap by investigating bovine brain tissue responses both before and after preconditioning. We employed a dual approach: experimental mechanical testing and computational modeling. Experimental tests were conducted to observe microstructural changes in mechanical behavior due to preconditioning, with a focus on axonal damage. Concurrently, we developed multiscale models using statistically repr

SUBMITTER: Mazhari A 

PROVIDER: S-EPMC11493751 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature