Development and validation of the UHPLC-MS/MS method for the quantitative determination of 25 PFAS in dried blood spots.

ABSTRACT: Per- and polyfluoroalkyl substances (PFAS) are anthropogenic fluorine-containing compounds largely used in industrial and consumer applications. They tend to bioaccumulate in the human body after intake from various sources in daily life. Following repeated exposure to PFAS, a broad range of adverse health outcomes has been reported. Consequently, monitoring PFAS levels in human blood is of paramount importance for public health policies. In contrast with traditional venipuncture, dried blood spots (DBS) constitute a reliable, cheap, and less invasive technique to allow microsampling by capillary blood collected on a specific device. This work aimed to develop and validate an innovative analytical method, combining quantitative DBS with UHPLC-MS/MS instrumentation to identify and quantify

SUBMITTER: Galletto M 

PROVIDER: S-EPMC11493788 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature