Diversity of transactivation regions of DMRT1 in vertebrates.

ABSTRACT:

Background

Doublesex and mab-3 related transcription factor (DMRT) 1, commonly found in all vertebrates, regulates the transcription of genes involved in the masculinization and maintenance of gonadal somatic cells and/or germline cell development. DMRT1 has a DNA-binding domain called the DM domain and a transcription regulatory region. Unlike the former, there is little knowledge about the latter transcription regulatory region. This study aimed to identify the transcription activation regions of DMRT1 from four species: humans and mice (mammals), leopard geckos (reptiles), and medaka (teleost fish), adding perspectives on evolutionary conservation and diversity.

Methods and results

For each species, several expression plasmids of deletion mutants were constructed, and the

SUBMITTER: Ishikawa N 

PROVIDER: S-EPMC11493790 | biostudies-literature | 2024 Oct

REPOSITORIES: biostudies-literature