Phase 1/2 Randomized Clinical Trial of In-clinic acupuncture Prior to Bacillus Calmette-Guerin in Patients with High-risk Non-muscle-invasive Bladder Cancer.

ABSTRACT:

Background

Treatment-related dose-limiting dysuria and irritative bladder symptoms are common in patients receiving intravesical bacillus Calmette-Guérin (BCG) to treat non-muscle-invasive bladder cancer (NMIBC). Acupuncture has been shown to reduce pain and urinary urgency/frequency in other patient populations.

Objective

To evaluate the feasibility, safety, and tolerability of weekly in-clinic preprocedural acupuncture among patients receiving induction BCG.

Design, setting, and participants

Patients with high-risk NMIBC undergoing induction BCG were randomized 2:1 to a standardized acupuncture protocol (acupuncture) versus the standard-of-care control arm.

Intervention

In-office acupuncture prior to each BCG instillation.

Outcome measurements and statisti

SUBMITTER: Psutka SP 

PROVIDER: S-EPMC11493842 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature